Total = df['MyColumn'].sum()
print (Total)
319
import numpy as np
import pandas as pd
df = pd.DataFrame({'a': [10,20],'b':[100,200],'c': ['a','b']})
df.loc['Column_Total']= df.sum(numeric_only=True, axis=0)
df.loc[:,'Row_Total'] = df.sum(numeric_only=True, axis=1)
print(df)
a b c Row_Total
0 10.0 100.0 a 110.0
1 20.0 200.0 b 220.0
Column_Total 30.0 300.0 NaN 330.0